A heart muscle disease believed to be caused by a deficiency of the mineral called selenium in the diet. Keshan disease genetic and rare diseases information. Keshan disease, a dilated cardiomyopathy affecting primarily children. Keshan disease uncountable a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus. It is a tickborne disease caused by transmission of bacteria to humans through the bite of infected. Keshan disease is a disease of heart muscle congestive cardiomyopathy which is potentially fatal. Keshan disease kd is an endemic cardiomyopathy of unknown cause and is named after keshan county in heilongjiang. Orange county moves forward with phase 2 of reopening. Keshan s disease keshan s disease heart gets bigger to increase surface area to catch selenium, pushes ribs out creating barrel chest, only found in china. Serum samples were collected from 112 kd patients and 112 normal controls.
It was first noted in the keshan province in heilongjiang, china. Sep 01, 2000 scientists in china noted that keshan disease had a seasonal and annual incidence that was more characteristic of an infectious disease than one caused by a nutrient deficiency. It is caused by a selenium deficiency and is characterized by pulmonary edema and heart failure. Kashinbeck disease definition of kashinbeck disease by. Keshan disease and selenium status of populations in china. Oxidative stress is involved in the pathogenesis of keshan disease an endemic dilated cardiomyopathy in china junruipei, 1 wenqifu, 2 liuyang, 3 zhiyizhang, 1 andyangliu 1 key lab of etiologic epidemiology of ministry of health, center for endemic disease control.
Oxidative stress is involved in the pathogenesis of keshan disease. Keshan disease is a congestive cardiomyopathy probably caused by dietary deficiency of selenium, named after keshan, where symptoms were first noted. Observations on effect of sodium selenite in prevention of keshan disease. It is hard to consider keshan disease preventable because the only way to ensure that the individual is getting enough selenium would be to test the soil in the area. Selenium deficiency also contributes to kashinbeck disease. The may 8 letter by carolyn hess reminded me of daniel patrick moynihans profound witticism. Provides a fully revised eleventh edition of the definitive reference to swine health and disease diseases of swine has been the definitive reference on swine health and disease for over 60 years. The main risk factor which causes keshan s disease is a deficiency of selenium in the diet, due either to not eating foods rich in selenium or in living in an area where there is little selenium in the soil and this contributes heavily on whether or not there is adequate intake of selenium in the diet. Keshan disease kd is a potentially fatal form of cardiomyopathy disease of the heart muscle endemic in certain areas of china. Adoption nutritionselenium deficiency keshan disease. Keshan disease kd is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. Keshan heart disease university of medicine and dentistry.
Roles of glycoproteins in the diagnosis and differential diagnosis of chronic and latent keshan disease article pdf available in molecules 225. Keshan disease is a potentially fatal disease of the heart. In the present study, the selenium levels of hair and food samples of kd in some endemic areas were measured. Host nutritional status and its effect on a viral pathogen. A detroit resident is tested for free for the coronavirus disease covid19 and antibodies at the sheffield center in detroit, michigan, u. Lyme disease therapeutics market size statistics, facts.
Keshan disease definition of keshan disease by medical. As one of several types of nutritional diseases, keshan disease is unique in that it. The incidence of the disease was dramatically reduced after the population was supplemented. Selenium deficiency is widely accepted as a fundamental cause of keshan disease kd. Surgical robots market rising case of acute and chronic. Keshan disease kd is a novel cardiomyopathy of unclear cause which only occurred in some poor rural areas of china, characterized by obvious yearly and seasonal prevalence as well as vulnerability for selfsufficient farming population, killing hundreds of thousands of people over last century. A fatal heart disease first reported in keshan county of the greater metropolitan qiqihar of the heilongjiang province, mainland china, which affects children and young women. Prediction of coexpression genes and integrative analysis. Kashinbeck disease expanding the spectrum of iodine. Keshan disease kd is a lifethreatening condition that affects the heart muscle. Blood and saliva were collected from 50 ckd, 50 lkd patients and 54 normal individuals. If keshan s disease is not diagnosed and treated, then it can result in heart failure due to the selenium deficiency.
Now with full color images throughout, this comprehensive and authoritative. Research article oxidative stress is involved in the. National laboratory of biomacromolecules, institute of biophysics, chinese academy of sciences, beijing 100101, china. Kashinbeck disease expanding the spectrum of iodinedeficiency disorders selenium, as selenocysteine, is an integral component of two important enzymes glutathione peroxidase and iodothyronine deiodinase that are present in many tissues, including the thyroid gland. Yang institute of health, chinese academy of medical sciences, beijing, peoples republic of china keshan disease is an endemic cardiomyopathy which was first observed in keshan county, heilonjiang province, northeast china. Here, we used stepwise multiple regression analysis to analyze the risk factors of the disease and the main. Chronic selenium deficiency may also occur in individuals with malabsorption and long term seleniumdeficient parenteral nutrition. It was later found to be prevalent in a wide belt extending from southwest to northeast china. To identify the key genes involved in seleniuminduced damage, we compared the expression profiles of seleniumrelated genes between patients with kd. For those who believe that a magical vaccine will end this plannedemic spelling is intentional, be aware. Keshan disease is a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackievirus, named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. Screening of tissues from keshan disease victims revealed the presence of a number of viruses, including coxsackieviruses 2. To identify the key genes involved in seleniuminduced damage, we compared the expression profiles of seleniumrelated genes between patients with kd and.
How scientists are thinking about reopening labs, and the. The prevalence of keshan disease in china international journal. Selenium and chronic heart failure ahaasa journals. He was also suffering from frequent attacks of cough and cold since 6 months of age which was marked prior to admission. Jan alexander, in handbook on the toxicology of metals fourth edition, 2015. To research the causes of keshan disease, consider researching the causes of these these diseases that may be similar, or associated with keshan disease. Keshan disease selenium for treatment of keshan disease. Southeast siberia and north korea are other affected areas. Keshan disease is a potentially fatal form of cardiomyopathy disease of the heart muscle. Keshan disease kd is an endemic cardiomyopathy, which mainly occurs in china. From 1984 to 1986, a national comprehensive scientific investigation on kd in chuxiong region of yunnan province in the southwest china was conducted. Pdf selenium level surveillance for the year 2007 of.
Molecules free fulltext roles of glycoproteins in the. Keshan disease is a cardiomyopathy that occurs in certain regions of china. Oxidative stress is involved in the pathogenesis of keshan. We read with interest the article by inoko et al about selenium deficiency, 1 but we do not agree with the interpretation of the data. Gene microarray was used to screen differently expressed genes. May 21, 2020 cdn newswire via comtex surgical robots. A condition caused by deficiency of the essential mineral selenium.
Fulminant heart failure due to selenium deficiency. More detailed information about the symptoms, causes, and treatments of keshan disease is available below symptoms of keshan disease. Pdf hivassociated cardiomyopathy is not keshan disease. However, molecular mechanism in the pathogenesis of kd remains poorly understood. A disorder of the bones and joints of the hands and fingers, elbows, knees, and ankles of children and adolescents who slowly develop stiff deformed joints, shortened limb length and short stature due to necrosis death of the growth plates of bones and of joint cartilage.
Keshan disease prevalent status surveillance in chuxiong. If you have problems viewing pdf files, download the latest version of adobe reader for language access assistance, contact the ncats public information officer genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Roles of glycoproteins in the diagnosis and differential. In any case, while still investigating the cause of keshan disease and the. Thus, if selenium supplementation did improve the condition. Symptoms of keshans disease health conditions vital. Keshan disease symptoms, diagnosis, treatments and causes. Risk factors for keshans disease health conditions vital. Keshan disease can lead to higher rates of cancer, cardiovascular disease and strokes. Tibet currently has the highest incidence rate of kbd in china. Keshan disease kd is an endemic cardiomyopathy of unknown cause and is named after keshan county in heilongjiang province where the disease was first identified in 1935. Institute of health, chinese academy of medical sciences. The disorder is endemic in some areas of eastern siberia, korea, china and tibet and is probably of. This prompted seleniums inclusion, and supported copper dosage reduction based on copper.
Jun 24, 2010 keshan disease kd is a dilated cardiomyopathy closely related with a diet deficient in the mineral selenium. Hivassociated cardiomyopathy is not keshan disease. Keshan disease genetic and rare diseases information center. Jan 10, 2018 keshan disease kd is a kind of endemic cardiomyopathy which has a high mortality. Western blotting processors market shows strong growth. Which of the following fruits is likely to be the best source of vitamin a. This new edition has been completely revised to include the latest information, developments, and research in the field. Clinical implications of basic research from the new england journal of medicine keshan disease, selenium deficiency, and the selenoproteome. Sep 18, 2008 an eight month old male infant with protein energy malnutrition was admitted in the hospital with the history of repeated attacks of convulsion since four months of age.
It is named for the northeastern chinese county keshan, where the disease prevalence is high because of seleniumdeficient soil. These symptoms were later found prevalent in young women and children in a wide belt extending from northeast to southwest china, a region with a seleniumdeficient soil. It is hard to consider keshan disease extremely preventable because the only way to ensure that the individual is getting enough selenium would. Keshan disease a congestive cardiomyopathy caused by a combination of dietary deficiency of selenium and the presence of a mutated strain of coxsackie virus characterized by heart failure and pulmonary edema.
Selenium deficiency is believed to play an important role in the pathogenesis of kd, but the molecular mechanism of seleniuminduced damage remains unclear. The infant had fair complexion, sparse fuzzy wooly hair with marked trunkal hypotonia. In asia and africa, dietary selenium deficiency is associated with a cardiomyopathy known as keshan disease and an osteoarthropathy called kashinbeck disease. Is selenium deficiency really the cause of keshan disease. Hivassociated cardiomyopathy is not keshan disease show all authors. Pdf selenium is an essential element for humans, animals and some.
Selenium deficiency was identified as a factor in the etiology of heart failure syndromes in areas of very low selenium intakes, such as china, where an endemic seleniumresponsive cardiomyopathy is called keshan disease. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in the soil is low. However, molecular mechanism in the pathogenesis of kd. Selenium deficiency causes myopathy as a result of the. The incidence of the disease was dramatically reduced after the population was supplemented with sodium selenite. While individuals who are diagnosed with a selenium deficiency and receive selenium supplements have been able to see some improvement in the continuing development of the disease, however, it can not reserve any of the heart muscle damage that has already occurred. White muscle disease, named because of its characteristic acolouration of the muscle is a myopathy caused by selenium deficiency in animals in the areas where the soil is low in selenium. Advertisement it has also been suggested that keshan s disease may be, at least partly due to infection by a virus coxsackievirus b3 cvb30, which would initially present with the typical viral infection symptoms such as.
Selenium deficiency and viral infection the journal of. Selenium supplements has been found to protect people from developing keshan disease but cannot reverse heart muscle damage once it occurs. The main symptom of keshan disease is myocardial necrosis, leading to weakening of the heart. It was first observed in keshan province in china, and it has since been found in other areas where the selenium level in. Saliva and serum lectin microarrays and saliva and serum microarrays were used to. Kashinbeck disease results in atrophy, degeneration, and necrosis of cartilage tissue in the joints.
These symptoms were later found prevalent in a wide belt extending from northeast to southwest china, all due to selenium. Lyme disease is a contagious disease caused by a bacterium species called borrelia burgdorferi. The body also becomes more susceptible to illness caused by other nutritional. Named for keshan county in heilongjiang province, where it was rampant in 1935 apei, 1937, the disease has also been recognized in many other locations. Once identified, the condition may be reversible via supplementation. In bureau of endemic disease prevention and control of the ministry of health, editor. Keshan disease is a cardiomyopathy endemic in children and pregnant women who live in the keshan region of china, where selenium levels in food are extremely low chen et al. Named after keshan county of heilongjiang province, northeast china, where symptoms were first noted. Expression profile analysis of seleniumrelated genes in. We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent keshan disease ckd and lkd, and screen the lectins as indicators of significant differences in glycoproteins of kd saliva and serum. Nutritional factors that may be protective against cancer include.
We aimed to explore the roles of glycoproteins in the pathogenesis of chronic and latent keshan disease ckd and lkd, and screen the lectins as indicators of signi. Keshan disease, selenium deficiency, and the selenoproteome. Keshan disease research group of chinese academy of medical sciences. Kashinbeck disease kbd is a chronic, endemic type of osteochondropathy disease of the bone that is mainly distributed from northeastern to southwestern china, including 15 provinces. Everyone is entitled to his own opinions, but not his own facts.
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